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Description

Remington et al

The new oral formulation of ALA has been reported to have the potential to overcome these pharmacokinetic limitations because it uses only the R-ALA enantiomer as a liquid solution, making it more soluble and stable in the gastric environment [101, 102]

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Importantly, both N-terminal FLAG-tagged and untagged WT IL-1 expressed in 293T cells were turned over at comparable rates to endogenous IL-1 in macrophages, and were degraded between 2 and 7 h following exposure to the protein synthesis inhibitor CHX (Figs