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The adoption of the PCPA-induced insomnia model in mice has enabled researchers to delve into the molecular mechanisms underlying sleep regulation (Hong et al., 2020), exploring the intricate interplay of cytokines (Wang et al., 2022), neurotransmitters (Lv et al., 2021), and their receptors

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For example, while FGF21 stimulates sympathetic activation in mice, elevations in cortisol that would suggest hypothalamic-pituitary-adrenal activation have not been observed in monkeys (239)

Tsuda 1999

Later numerous transcriptome-wide investigations proved that distinct groups of GST s are markedly induced in the early phase of bacterial, fungal and viral infections