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The research, much of it coming from university labs, is new and remains controversial, but practitioners say that these discoveries have helped move the needle for some chronically ill patients for the first time in years

An unhealthy gut can cause a "leaky gut," allowing harmful substances like LPS (10) from certain bacteria to trigger inflammation

Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling

While these findings highlight the potential of EMS as a complementary strategy, future research could explore its application in clinical populations with limited physical capacity, where traditional RT may be less feasible (Thapa et al., 2023)

A tryptophan-deficient diet leads to more severe EAE, whereas tryptophan supplementation reverses this effect, suggesting that tryptophan metabolites exert their functions through activation of AhR in microglia