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Accompany with the report of ferroptosis, researchers found that many natural compounds, including dihydroisotanshinone I, 98,99 solasonine, 100 DMOCPTL, 101 cucurbitin B, 102 and honokiol 103 could induce ferroptosis by inhibiting GPX4 activity or reducing GPX4 protein level

149 Furthermore, certain drugs like amitriptyline, commonly prescribed for depression, have been found to bind reversibly to the G-sites of GSTP1 and GSTA1, leading to a significant reduction in their activity

Furthermore, we observed no significant effect on mtDNA copy number in the knockout or treatment, consistent with unchanged MIC60 expression levels, which is known to play a role in nucleoid organization (Fig

For instance, in Ghana, many hypertensive patients prioritize Divine Healing over evidence-based treatments due to strong religious convictions (196, 197)