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All participants received a treatment dosage once a week for 32 weeks

Upon reperfusion, the restoration of blood flow exacerbates the inflammatory response through the formation of reactive oxygen species (ROS) and the activation of immune cells such as neutrophils and macrophages

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This paper presents, for the first time to the authors knowledge, an untargeted metabolomics study of the polar metabolome of untreated MDA-MB-231 parental (cDDP-sensitive) cells and derived MDA-MB-231/R cells (cDDP-resistant), the latter having been previously established as a model of acquired cDDP-resistance [30]