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One such model is the rat model treated with 6-OHDA

However, it has been shown that eumelanin induces ROS generation both dependently and independently of UV 41

[6] [7] In silico modelling suggest that it has effects on thyroid hormone receptors

Conclusion This review summarizes the evidence supporting the important role of ferroptosis in AD pathology and presents what is known about the targets for its inhibition for a potential treatment