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Cui Q, et al

2023;9:e15333

doi: 10.1016/j.phrs.2018.06.007

Specifically, bloodletting puncture can suppress the expression of MAPK, ERK, p38, and their downstream molecules, MMP9 and AQP4, leading to enhanced neurological function, reduced brain edema, stabilization of the bloodbrain barrier, and decreased apoptosis

Thus, the researchers concluded that this interaction may potentially shield islets against the detrimental effects of proinflammatory cytokines, which might be released by activated macrophages or as a result of the transplantation procedure itself