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Nikkhah-Bodaghi M, Maleki I, Agah S, Hekmatdoost A

Human hepatoma cells (HepG2) are widely used as an in vitro model to study the effects of several xenobiotics in hepatocytes [37, 38]

One trial suggests it may help reduce weight in overweight people with diabetes when used as an add on to the anti-obesity drug orlistat [2]

Melatonin exerts its beneficial effects in NAFLD exosomal therapy by activating Bmal1 expression in adipocytes (257)

More significantly, MOTS-c administration shifted the trajectory of age-related metabolic decline, indicating that the peptide's benefits are not limited to preventing dysfunction in young animals but can partially reverse established decline [2]