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Written informed consent for participation was obtained from the participants in accordance with the national legislation and institutional requirements

Endothelial cells respond to changes in environmental conditions, e.g., hypoxia, glucose deprivation, and blood flow-mediated shear stress activates AMPK to promote catabolic pathways in endothelial cells by fatty acid oxidation to produce energy [169, 229, 230]

They also reported that the administration of lipopolysaccharide (LPS) in vivo resulted in NF B activation in macrophages harvested from PARP wild-type, but not PARP-1 knockout, mice (973)