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In the CNS, mitochondrial function is essential for sustaining neuronal energy balance, thereby supporting synaptic activity and neuron viability

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However, excessive glutamate release can cause over-activation of neuronal glutamate receptors, leading to neuronal oxidative stress [3, 4], mitochondrial damage [5], and disruption of Ca 2+ homeostasis [6, 7]

They also observed that resveratrol increased SIRT2 levels, upregulated the mRNA expression of glycolysis- enhancing enzymeshexokinase 2 (HK2), lactic dehydrogenase A (LDHA), and pyruvate kinase M2 (PKM2)and shifted the concentration of glycolytic products (reduced pyruvate and elevated lactate), promoting glycolysis (45)

N-terminally truncated isoforms (N) lack the transactivation domain and appear to act in a dominant-negative manner by either competing with the TA isoforms of p63 and p53 for DNA binding sites or by direct protein interaction