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Financial disclosure The authors have the following to disclose: support provided by the Ministry of Health and Welfare (HI21C0694, Development of treatment for intractable skin diseases using low-molecular compounds with enhanced Wnt/beta-catenin), Republic of Korea

In Japan, ALT level of 31U/L and HBV-DNA3.3 log IU/ml (2000IU/ml) is considered as a criterion, regardless of HBeAg positive/negative status

doi: 10.3390/nu12113273 36 SyafiqRSapuanSMZuhriMYMIlyasRANazrinASherwaniSFKet al

The structure reveals how AS408 stabilizes the inactive conformation of this switch, thereby acting as a negative allosteric modulator for agonists and positive allosteric modulator for inverse agonists