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Further in vitro studies showed that the combination of EGCG and warfarin protected HUVECs from oxidative stress and prevented apoptosis, and the specific mechanism involved the inhibition of HIF-1-mediated activation of PI3K/AKT and ERK1/2 signaling (144)

coli strain JX33, that allows the incorporation of multiple UAAs in one protein and genome wide amber codon replacement (Isaacs et al., Conflict of interest statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest