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In the majority of cancer types, most of the in vivo studies have shown inhibition of tumour growth (4060%) by using elevated doses of ascorbate (1-4 g/kg) either intravenously (IV) or intraperitoneally (IP) [15, 55,56,57]

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However, despite TIM is known to be highly dependent of cholesterol biosynthesis (161164), its interplay with MVA biosynthetic pathway and STAT signaling, remains unexplored

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