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Quantifying the economic burden of IC/BPS on the American health care system is difficult because of the lack of an objective marker for diagnosis, resulting in uncertainty regarding its true prevalence

Suggested use is 1 capsule per day

Therefore, although naringenins low water solubility can support BBB permeability in theory, its poor pharmacokinetic profile necessitates formulation strategies such as nanoparticles or liposomes to ensure effective delivery to the central nervous system

A tight balance of inflammatory mediators is crucial for normal physiological processes in the CNS, including synaptic plasticity and behavioral outcomes