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the antibody genes are inserted into the expression vector by standard methods (e.g., ligation of complementary restriction sites on the antibody gene fragment and vector, or blunt end ligation if no restriction sites are present)

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This review discusses the development of TRIs and emphasizes the importance of evaluating their effects on brain transporters to ensure their efficacy in humans

However, GSSG levels did not change substantially with aging in most of the 10 brain regions measured but declined significantly between 15 and 23 months of age in the brainstem, thalamus, and hypothalamus, while taurine levels also declined slightly ( C57BL/6J male mice showed a mean lifespan roughly 8% longer than C57BL/6N males, while C57BL/6J female mice showed a mean lifespan roughly 5% longer than C57BL/6N females (Ogiso et al., 2025)