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118 The mitochondrial E3 ligase, SCF FBXL4 , which is composed of the adaptor protein S-phase kinase-associated protein 1 (SKP1), a Cullin 1 (CUL1) backbone, and the mitochondrially localized F-box protein FBXL4, binds RING-box protein 1 (RBX1) and E2 ubiquitin-conjugating enzyme to ubiquitinate BNIP3 and NIX for proteasomal degradation

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