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Higher NAD enhances SIRT1 activity, promoting fat oxidation and mitochondrial remodeling via PGC-1 pathwaysmechanisms consistent with improved endurance and recovery potential (Cant et al., Cell Metabolism

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Cecal levels of Erysipelatoclostridium abundance have been positively correlated with dyslipidemia 93 , and a report that WD decreased the relative abundance of Erysipelatoclostridium and that the abundance of Erysipelatoclostridium negatively correlated with obesity-related indices 90 may partially explain our observation that decreased levels of Erysipelatoclostridium were present in the 5A-1MQ-treated group and the WD control group relative to the vehicle-treated group switched from WD to LD

doi: 10.1016/j.celrep.2014.06.007