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However, activation of the IKK kinase complex results in IB degradation, facilitating NF-B nuclear translocation and upregulation of pro-inflammatory genes, including Interferon gamma (IFN-), transforming growth factor beta (TGF-), interleukin (IL)-1, monocyte chemoattractant protein 1 (MCP-1), IL-6 and TNF-

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For group comparisons, we used a Wilcoxon test to estimate significant differences between the median GESECA score per group

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