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Anti-obesity drug discovery: advances and challenges

Therapeutic targeting of Glutaminolysis as an essential strategy to combat cancer

TECs: tubular epithelial cells

It can change various mitochondrial-related functions, including increasing the production of mitochondrial ROS, reducing mitochondrial transmembrane potential, and changing mitochondrial calcium homeostasis ( in vivo and in vitro through c-Raf and MEK (Figure 5) (Schaedler et al., 2010)