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Moreover, biochemical disturbances caused by A are accompanied by substantial cytoskeleton abnormalities and consequently impaired axonal transport [26]

As such, most approaches to delivery have utilized gene therapy methods with the hope that the growth factor will be expressed in the correct location at a high enough concentration and for a long enough period to provide clinical relief

However, the prolonged accumulation of senescent cells can paradoxically induce cancer development and various age-related diseases by inducing an inflammatory environment via the SASP 47-49

These reactions occur even in solid-state storage, though much more slowly than in solution