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This discovery represented a major advance in understanding enzymatic antioxidant defence mechanisms and highlighted the biological importance of selenium, which was later recognised as an essential trace element due to its role in selenoproteins such as GPx

These cells, in turn, secrete cytokines and ROS, further enhancing ferroptosis (108)

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Based on this evidence, it can be concluded without any reasonable doubt that oxidative stress puts some babies and children at risk of paracetamol-induced neurodevelopmental injury, and that postnatal exposure to paracetamol in those susceptible babies and children is responsible for many if not most cases of ASD. Sil A, Ravi MD, Patnaik BN, et al

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