glutathione synthetase deficiency schizophrenia

glutathione synthetase deficiency schizophrenia and glutamate in schizophrenia: a 7T MRS study Inborn errors in the metabolism

Name: glutathione synthetase deficiency schizophrenia and glutamate in schizophrenia: a 7T MRS study Inborn errors in the metabolism
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SKU: 55022544006
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Inborn errors in the metabolism of glutathione Orphanet Journal of Rare Diseases Springer Nature Link Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence PNAS A comprehensive review on schizophrenia: epidemiology, pathogenesis, diagnosis, conventional treatments, and proposed natural compounds used for management Naunyn Schmiedeberg's Archives of Pharmacology Springer Nature Link Schizophrenia and Glutathione: A Challenging Story Altered serum glutathione disulfide levels in acute relapsed schizophrenia are associated with clinical symptoms and response to electroconvulsive therapy BMC Psychiatry Springer Nature Link

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Description

Q.WangC.YangP.WangK

Of the glutathionylation-related enzymes, the glutathione S-transferases (GSTs) superfamily was classically identified as phase II detoxifying enzymes that contribute to neutralizing exogenous as well as endogenous electrophiles, including ROS, through the conjugation of glutathione (GSH) 9,10,11

Initially, ubiquitin-activating enzyme E1 binds with ATP to activate the ubiquitin molecule, forming a thioester bond between the carboxyl group of ubiquitins C-terminal and the cysteine residue of the E1 enzyme