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The MAPK family comprises three major subfamilies: ERK (a pro-survival kinase activated by mitogenic signals), and the stress-responsive MAPKs, JNK and p38 (Sugiura et al., 2021)

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10.1016/j.yexcr.2017.04.016 90 JasialS.GilbergE.BlaschkeT.BajorathJ

The low initial dose is recommended, and increase incrementally, titrating to effect ( Cyproheptadine is a first-generation antihistamine used in GI disorders for its serotonin (5HT2) and calcium channel antagonist effects (143, 144)