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57 This methylation system is quantitatively by far the predominant NAM scavenging pathway under most conditions

doi:10.3389/fneur.2014.00227

10.1523/jneurosci.4061-15.2016 40 MarshallG

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Objectives The primary aim is to test the hypothesis that daily treatment with 400 mg oral SAMe for 180 days will lead to a greater reduction from baseline in plasma levels of p-tau181 compared to placebo in patients with mild cognitive impairment or dementia due to AD