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Mancias JD, Pontano Vaites L, Nissim S, Biancur DE, Kim AJ, Wang X, et al

Instead of merely inhibiting the active sites of proteins and reducing their activity, DUB inhibitors can completely degrade the target proteins, effectively eliminating the residual activity that often leads to side effects with traditional drugs

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241 In addition, there is evidence that corticosteroids cannot inhibit p38MAPK activation, and that p38MAPK inhibitors combined with corticosteroids enhance the inhibitory effect of corticosteroids on cytokines produced by macrophages in patients with COPD mediated by LPS

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