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J Clin Invest 125:583592 Acknowledgements The authors would like to acknowledge funding from NIH grants RO1-CA166907 and RO1-DC016835 (to V.R.) and RO1-DC002396 (to L.P.R.), which support studies from the authors laboratories described in this review

doi: 10.1111/j.1365-2133.1990.tb16121.x 88 YoonJEKimYKwonSKimMKimYHKimJ-Het al

For instance, scheduling thrombolytic therapy to coincide with peak permeability could reduce hemorrhagic complications (163, 164), while nanocarrier-based systems show enhanced BBB penetration during specific circadian windows (165, 166)