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Of these materials, only phenylalanine is produced in sufficient quantities, at normal aspartame intake levels, to cause concern

Pronovost et al., 2023

Downregulation of detoxifying and mitochondrial proteins indicates compromised redox homeostasis and oxidative phosphorylation, predisposing the liver to toxic metabolite accumulation, oxidative damage, and inflammation (Staffas et al., 1998)

Sex-dependent differences in pain sensitivity were shown recently in paclitaxel-treated rats with CIPN symptoms [130], and it has been demonstrated that the lipopolysaccharide-induced activation of spinal TLR4 mediates mechanical allodynia in male mice but not in female mice

Gas and bloating play a role, too