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These models ensure therapeutic agents are delivered at optimal times and doses, maximizing efficacy while minimizing systemic toxicity

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Lactate accumulation also induces the transition of M1-type macrophages to M2-type macrophages through the modification of histone lactylation, which acts as a lactate timer [359]

Benvenga S, Vita R, Di Bari F, Granese R, Metro D, Le Donne M (2019) Stable consumption of swordfish favors, whereas stable consumption of oily fish protects from, development of postpartum thyroiditis