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a , Scheme of the in vitro sgRNA competition assay performed in HEK-293T SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA transduced with a pool of 5 control sgRNAs (sgControl, gray) and sgRNAs targeting TXNRD2 (pink) and SLC25A40 (green) (left)

First-degree relatives of vitiligo patients have a 68% risk of developing the disease, and the concordance rate between monozygotic twins is approximately 23%.28,34 Five genome-wide association studies (GWAS) have been conducted on vitiligo in European and Asian populations, identifying at least 54 vitiligo susceptibility loci.49,50 Human leukocyte antigen region Several genes within the human leukocyte antigen (HLA) region, specifically in class I and II regions, are associated with vitiligo

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PD and IBD are linked to mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which is implicated in microbial immunological signaling (95)

M., Weise, S