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Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the App(NL-G-F/NL-G-F) knock-in mouse model of Alzheimers disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior

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These discrepancies in the effects may stem from several factors, including differences in experimental protocols, animal models, dosages, treatment durations, and the brain regions studied

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