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Curr Pediatr Res 2023;27:1968-70

Discontinue use if adverse effects occur

There were several flaws in these studies such as being-underpowered or not having well-designed (Kenefick et al., 2002

Increased activity of both ERK1/2 and p38 increase the phosphorylation and subsequent activity of ternary complex factor (TCF) and serum response factor (SRF) (Vickers et al

Moreover, animal experiments allow researchers to investigate the interactions between apical lesions and systemic conditions, such as cardiovascular diseases (Brilhante Wolle et al., 2012) and diabetes (Prieto et al., 2017)