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Disruption in the gut upsets the communication flow between the gut and the brain

The real hurdle came in the Phase IIb trials

Eur J Pharmacol 379:1931 Jelovac N, Sikiric P, Rucman R et al (1999b) The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam