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Endometrial tissue repair The endometrium is the only human tissue that undergoes periodic breakdown and regeneration, necessitating a transition of tissue cells between mesenchymal and epithelial phenotypes, a process known as mesenchymal-epithelial transition and epithelial-mesenchymal transition [470, 471]

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This triggers neuronal membrane depolarization, increased potassium efflux, and sodium influx, disrupting Ca 2 -ATPase function and leading to high intracellular calcium levels [12, 55]