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Study plasma and/or metformin-spiked plasma calibrator samples were extracted via protein precipitation with acetonitrile and centrifuged

The authors also found that the inhibition of ROS level and iNOS expression by curcumin is in tandem with the over expression and antagonization of anti-apoptotic protein, Bcl-2, thus suggesting a synergistic role of Bcl-2 in curcumin-induced protection [49]