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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial

Peer-review model: Single blind Specialty type: Gastroenterology and hepatology Country of origin: Sri Lanka Peer-review reports classification Scientific Quality: Grade C Novelty: Grade B Creativity or Innovation: Grade B Scientific Significance: Grade B P-Reviewer: Tajiri K S-Editor: Wei YF L-Editor: A P-Editor: Zhang L Contributor Information Arjuna Priyadarsin De Silva, Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka

Topical application of Centella asiatica in wound healing: recent insights into mechanisms and clinical efficacy

We also validate these observations through hDAT-like mutagenesis in the subsite C region of dDAT that leads to a loss of affinity towards the NRIs used in the study

Mutation of U597 to serine resulted in sustained thiolate-FAD charge transfer absorption and loss of the ability to reduce Trx, indicating that the C596-U597 disulfide functions in the catalytic sequence to receive electrons from the C154 C159 pair and distribute them to Trx