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Mathematical Modeling with Excel , Jones & Bartlett Learning, p

During DNA replication, DNA polymerase misincorporates thymine (T) opposite O 6 -MeG, rather than cytosine (C), which is the correct partner for guanine.Normal cells typically contain a greater number of G-C base pairs than malignant cells, a phenomenon attributed to the mispairing of O 6 -MeG with thymine, which leads to a reduction in methylatable cytosine residues