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Zhang L, Gong X, Tan J, Zhang R, Li M, Liu C, et al

Increased performance Reply 10 people found this helpful

Decreased mitochondrial CoA results in decreased N-acetylglutamate which is a needed cofactor for carbamoyl phosphate synthetase 1 (CPS 1), the primary enzyme responsible for incorporating ammonia into the urea cycle, where 90% of ammonia is converted to urea (see Figure 2)