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While numerous animal experiments and in vitro studies have provided preliminary evidence for the feasibility of these metabolites, their actual efficacy and bioavailability in the human body still require more rigorous, large-scale clinical trials to be confirmed

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These mitochondria are a primary source of ROS, making the kidneys especially susceptible to oxidative stress-related injury

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[1] Although sodium bicarbonate has been employed in clinical medicine for more than a century, contemporary guidelines urge a judicious, physiology-guided approach rather than routine empirical use