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Whereas endothelial cells may be more involved in vascular reconstruction and repair under ischemic conditions, the regulation of mitophagy may be more focused on modulating cellular barrier function and vascular responses [62]

Adrenal insufficiency: Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use

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Chatterjee SN stated that the permeability of the membrane has also been found to be increased in parallel with the lipid peroxidation indicating that the interior of the membrane undergoes alterations [17].Wolff SP et al stated that free radicals and oxidative stress may act as a common pathway to diabetes itself as well as to its later complications & found significantly higher lipid peroxide levels in diabetic than healthy individuals, matching our study results [18]