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In dogs with phenobarbital-associated toxicosis, clinical, biochemical, and histologic improvement can occur if the drug is discontinued or used at a reduced dosage prior to severe, end-stage liver disease

Second, GCH1 remodels the lipid membrane environment by promoting the uptake of PUFA-PL, an inducer of ferroptosis, while increasing CoQ10 (CoQ10H 2 ) levels, thereby counteracting lipid peroxidation