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doi: 10.1016/j.regpep.2004.08.031 32 KaiyaH.KojimaM.HosodaH.KodaA.YamamotoK.KitajimaY.et al

Its skin-lightening effect was detected incidentally

By showing a working example of the methodology that led to a synthetic prodrug capable of in vivo activation in mice, it is expected that interest in this field will grow and eventually spur the development of not only other cases of synthetic prodrugs, but also therapeutic applications of artificial metalloenzymes