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10.1038/s41581-023-00694-0 95 SasakiY.Raza-IqbalS.TanakaT.MurakamiK.AnaiM.OsawaT.et al (2019)

This fundamental biochemical role has established it as a cornerstone in metabolic and bioenergetic research

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As serum homocysteine (Hcy) and methylmalonic acid levels were identified as predictive factors for severe toxicity caused by pemetrexed, patients now receive vitamin B12 (B12) and folic acid (FA) supplementation before pemetrexed-containing chemotherapy [4]