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RUNX3 promoter hypermethylation is frequent in leukaemia cell lines and associated with acute myeloid leukaemia inv(16) subtype

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Certain processes, such as mechanoreceptor activation and glutamate release, occur almost instantaneously following injury, whereas others, including immune cell infiltration and the full manifestation of oxidative stress, develop over a period of hours to days

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This redirection of tryptophan also increases glutamatergic excitation, thereby potentiating symptoms

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