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Interestingly, supernumerary nipples have been associated with numerous diseases, most prominently urogenital disorders ( Conclusions and Perspectives The retention of areolas/nipples in male rodent offspring after in utero exposure to chemicals is a sign of perturbed androgen action during critical stages of the masculinization programming window. As adverse outcomes that can be observed in intact animals (as currently required to categorize a chemical substance as an EDC from a regulatory point of view), both NR and AGD are essentially markers for the same mode of action: anti-androgenic

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