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We induced abdominal compartment syndrome (intra-abdominal pressure in thiopental-anesthetized rats at 25 mmHg (60 min), 30 mmHg (30 min), 40 mmHg (30 min), and 50 mmHg (15 min) and in esketamine-anesthetized rats (25 mmHg for 120 min)) as a model of multiple occlusion syndrome

Epithalon's primary mechanism involves the activation of telomerase, the enzyme responsible for maintaining and elongating telomeresthe protective DNA-protein structures at the ends of chromosomes that naturally shorten with each cell division

the inclusion complexes containing more than 80% of the drug by the end of 192 h [31]

Understanding why this variability exists requires examining the mechanisms more closely

10.1136/jmedgenet-2015-103023 J