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Our findings are in agreement with other recent observations using similar ligature models, which show a considerable increase of the distance between the cemento-enamel junction and the alveolar crest, regarded as a sign of alveolar bone loss (48, 52)

MOTS-c prevents diet-induced obesity and insulin resistance by improving glucose utilization and maintaining adipose homeostasis [5]

Open question Whether the same mechanisms are clinically meaningful in humans is not yet established

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