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10.1016/j.jinorgbio.2022.111750 62 LiK.WuL.WangH.FuZ.GaoJ.LiuX.et al (2024)

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Traditional diagnostic methods typically depend on clinical symptoms or the identification of individual pathogens

Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes