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Figure 2 3.1 Metabolic effect of KD and -HB In this context, KD can influence tumor cell growth by lowering insulin and insulin-like growth factor-1 (IGF-1) levels, thus reducing one of the most common oncogenic pathways such as PI3K-Akt-mTOR implicated in tumor cell proliferation and tumor growth ( Particularly, KBs produced by KD participate in various cellular processes as signaling molecules, regulate inflammation and OxS

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TGF1 signaling stimulates the transcription of a cascade of genes related to ECM production, including collagens and fibronectin, and activation of myofibroblasts, which express -SMA 51,52

ADVICE Treatments must be avoided in those with known allergies to thioctic acid, vitamin C or glutathione