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Limitations and risks of meta-analyses of longevity studies

spicamycin D

established a destabilization of the medial meniscus (DMM)-induced osteoarthritis (OA) model in 8-week-old wild-type and AMPK (adenosine 5-monophosphate (AMP)-activated protein kinase, AMPK) -knockout mice, and conducted an in vitro study using chondrocytes exposed to interleukin-1 (IL-1) to mimic an OA microenvironment