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Upon stimuli, PI3K produces PtdIns(3,4,5)P3 which binds to AKT and 3-phosphoinositide-dependent protein kinase (PDK1)

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10.1016/j.cellsig.2023.111015 56 LiuY.HuoJ.-L.RenK.PanS.LiuH.ZhengY.et al (2024)

A naturally occurring substance called Genipin, which comes from Gardenia jasminoides, may be a sensitizer to accelerate oxaliplatin-induced cell apoptosis and autophagy

Uptake of the soluble 7ACh receptor/-amyloid complex by astrocytes triggers Ca 2+ influx, followed by glutamate secretion, which induces excitotoxicity and neuronal death (Fig